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URONABOL
High-Purity Ursolic Acid (3β-hydroxyurs-12-en-28-oic acid)
Most ursolic acid supplements test at 20% purity or lower. Uronabol is HPLC-tested to verify actual ursolic acid content. See the lab results in the image gallery.
A peptide-mimetic compound that activates mTOR/IGF-1 pathways without hormonal suppression. Non-suppressive. No PCT required. Works for natties, between cycles, or stacked with TRT.
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The Purity Problem Nobody Talks About
Most ursolic acid supplements are severely underdosed
HPLC chromatography results — Uronabol batch verification
⚠️ TYPICAL "URSOLIC ACID" SUPPLEMENTS
Most brands use rosemary or apple peel extract standardized to only 10-20% ursolic acid. A "500mg" capsule may contain only 50-100mg of actual active compound. The rest is filler.
✓ URONABOL — HPLC VERIFIED
Every batch is tested via High-Performance Liquid Chromatography to verify actual ursolic acid content. You're getting what the label says — not a diluted extract with 80% inactive material.
Let's Be Clear: What Uronabol Won't Do
We respect your intelligence. Here's the honest picture.
❌ It won't replace actual anabolics
Ursolic acid is not testosterone, not a SARM, not a prohormone. If you're expecting steroid-like gains, look elsewhere. This is a natty enhancer — not a replacement for gear.
❌ Human RCT data is mixed
The Lobo et al. 2021 RCT found no additional hypertrophy or strength benefit in young men already on a high-protein diet and structured training program. Both groups gained ~1.1kg of muscle — UA didn't add extra. We include this study because you'd find it anyway.
❌ It takes time
This isn't a quick fix. Animal studies ran 6-17 weeks. Human studies ran 8 weeks minimum. If you're looking for instant results, this isn't it.
✓ So why use it?
The animal data is compelling. The mechanism (mTOR/IGF-1 activation, ATF4 inhibition) is well-documented. The Bang et al. pilot showed reduced muscle damage markers. It's non-suppressive, legal, and stacks with anything. For natties, between cycles, or on TRT — it's a low-risk addition with legitimate scientific backing.
The Published Research
Peer-reviewed studies — not marketing claims
Kunkel et al., 2011 — Cell Metabolism
MOUSE MODELUA identified via mRNA-signature screening as a compound that opposes atrophy. Mice given UA showed ~7% increased muscle mass in fasting-induced atrophy conditions. In healthy mice, UA caused muscle hypertrophy and strength gains vs. controls. Effects linked to enhanced insulin/IGF-1 signaling and reduced atrophy gene expression.
"UA both reduces atrophy and enhances hypertrophy" — Kunkel et al.
Kunkel et al., 2012 — PLoS ONE
MOUSE MODEL6-17 week study on high-fat diet mice. UA-treated mice showed: increased skeletal muscle mass, larger fiber diameters (fast & slow fibers), improved grip strength, and longer treadmill running time. Also reduced adiposity, improved glucose tolerance, and expanded brown fat depot.
"Ursolic acid increased skeletal muscle mass, grip strength and exercise capacity" — Kunkel et al.
Bongers et al., 2015 — J. Biol. Chem.
AGED MOUSE MODELExamined UA's effects on age-related muscle loss. Aged mice treated with UA had higher muscle weight, fiber size, grip strength, and muscle quality vs. untreated old mice. Mechanism: UA inhibited ATF4, a transcription factor identified as a key driver of muscle atrophy in aging.
"UA is a promising agent for reducing weakness and atrophy in aged skeletal muscle" — Bongers et al.
Ogasawara et al., 2013 — Resistance Exercise Model
RAT MODELRats given UA after muscle contractions showed sustained mTORC1 activation (p70S6K phosphorylation) up to 6 hours post-exercise, while controls returned to baseline. This suggests UA helps maintain protein synthesis pathways active for longer.
"UA is able to sustain resistance exercise-induced mTORC1 activity" — Ogasawara et al.
Human Trials (Limited Data)
Bang et al., 2017 — Pilot Study
HUMAN8-week pilot in resistance-trained men (450mg UA/day). UA group showed significantly lower post-exercise muscle damage markers — CK, LDH, CK-MB, and BNP all decreased (p<0.05). Suggests improved recovery. Trends toward better body composition but not statistically significant in small sample.
Lobo et al., 2021 — RCT (Null Result)
HUMAN8-week double-blind RCT in 22 young men (400mg UA/day). All on structured training + high-protein diet (~1.6g/kg). No significant difference between UA and placebo. Both groups gained ~1.1kg muscle and similar strength. Conclusion: "UA had no synergic effect on muscle strength and mass in response to resistance training in physically active men consuming a high-protein diet."
We include the null result because you're not beginners. The mechanism is sound, animal data is strong, but human trials are mixed. Make your own call.
The Mechanism: How Ursolic Acid Works
Four documented pathways — not marketing buzzwords
mTORC1 Activation
Enhances p70S6K phosphorylation — the master switch for protein synthesis. Ogasawara 2013 showed sustained activation up to 6 hours post-exercise.
IGF-1 Signaling
Kunkel 2011 found UA enhances insulin/IGF-1 pathway activation, increasing Akt activity and downstream anabolic signaling without exogenous hormones.
ATF4 Inhibition
Bongers 2015 identified ATF4 as a key driver of muscle atrophy in aging. UA inhibits this pathway, potentially reducing age-related and stress-induced muscle breakdown.
Atrogene Suppression
Downregulates MuRF1 and Atrogin-1 — the ubiquitin ligases responsible for muscle protein breakdown. Anti-catabolic effect via SIRT1 activation (Liao 2023).
Non-hormonal. Does not interact with testosterone, estrogen, or require PCT.
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Three Use Cases Where Uronabol Makes Sense
Non-suppressive means it fits multiple protocols
The Natty Enhancer
You've drawn the line — no hormones, no SARMs, nothing that suppresses. But you want every legal edge available. Ursolic acid activates mTOR/IGF-1 signaling without touching your HPTA.
Best for: Lifters who want to stay natural but maximize their genetic potential. Run year-round if desired — no cycling required.
The Bridge Compound
PCT is over. You're recovering. But you still want to maintain and potentially build while your system normalizes. UA won't add suppression on top of what you're already dealing with.
Best for: Post-cycle or cruise phases when you need anti-catabolic support without additional hormonal load. The ATF4 inhibition mechanism may help preserve gains during recovery.
The Clean Stack Add-On
You're on TRT and want to add something that won't complicate your protocol or bloodwork. UA doesn't interact with testosterone or estrogen pathways. No impact on your E2, no liver stress.
Best for: TRT patients who want an additional anabolic signal without adding orals, injectables, or anything that requires monitoring. Stacks clean.
User Reports
Anecdotal feedback from verified buyers — not clinical data
"Ran it for 12 weeks alongside my normal training. Noticed improved recovery by week 3-4 — less soreness, could push harder on subsequent sessions. Muscle density seemed to improve, though hard to quantify. No sides, no changes in mood or libido. For a natty compound, I'm satisfied. It's not magic, but it's something."
"Added this to my TRT protocol because I wanted something that wouldn't mess with my bloodwork. 8 weeks in — no changes to my E2 or hematocrit. Pumps feel better, staying fuller throughout the day. Is it placebo? Maybe. But my last bloodwork was clean and I feel like training is more productive. Will continue."
"Using this during PCT and cruise. The anti-catabolic angle interested me — I always lose more than I should post-cycle. This time felt different. Held more fullness, strength didn't drop as much. Could be coincidence, could be the UA. Either way, it's cheap insurance and doesn't add suppression. That's the value proposition for me."
Individual results vary. These are user reports, not guaranteed outcomes. The Lobo 2021 RCT found no significant difference in muscle gain between UA and placebo in young trained men on adequate protein.
Protocol & Dosing
Based on research dosages and user feedback
Daily Dose
1 serving (2mL)
Human studies used 400-450mg/day. Take in the morning or 30 minutes pre-workout.
Duration
8-16+ weeks
Animal studies ran 6-17 weeks. Human studies ran 8 weeks. Longer may be better — non-suppressive so no need to cycle off.
PCT Required?
No
Does not interact with testosterone, estrogen, or any hormonal pathway. No recovery protocol needed.
Optimal Timing
Pre-workout
Ogasawara 2013 showed post-exercise mTOR activation with acute dosing. Pre-workout may amplify training response.
📊 DOSING CONTEXT FROM RESEARCH
Bang et al. 2017 used 450mg/day and saw reduced muscle damage markers. Lobo et al. 2021 used 400mg/day with no ergogenic effect in well-trained men on high protein. Animal studies used higher relative doses (200-300mg/kg in mice, not directly translatable to humans). The optimal human dose is still being established — current products are based on the limited clinical data available.
Frequently Asked Questions
"Why should I believe this when the human RCT showed no effect?"
Fair question. The Lobo 2021 RCT found no additional benefit in young men already on a high-protein diet (~1.6g/kg) with structured training. Both groups gained ~1.1kg of muscle. However: (1) The pilot study (Bang 2017) showed significantly reduced muscle damage markers, suggesting recovery benefits that may not show up in 8 weeks. (2) The animal data across multiple models is consistent and robust. (3) The mechanism (mTOR/IGF-1 activation, ATF4 inhibition) is well-documented. Our position: UA may provide more benefit in scenarios of stress, deficit, or suboptimal conditions than in already-optimized young men. It's not a miracle — it's a marginal edge with a sound mechanistic basis.
"What makes Uronabol different from cheap ursolic acid on Amazon?"
Purity. Most ursolic acid supplements use rosemary or apple peel extracts standardized to only 10-20% actual ursolic acid. A "500mg" capsule may contain 50-100mg of active compound — the rest is plant matter. Uronabol is HPLC-tested for actual ursolic acid content. You can see the chromatography results in the image gallery. If you're going to run a compound based on research that used pure UA, you need a product that actually delivers pure UA.
"Will this affect my bloodwork if I'm on TRT?"
Based on the mechanism and user reports: no. Ursolic acid doesn't interact with testosterone, estrogen, or any hormonal pathway. It works at the cellular level via mTOR/IGF-1 signaling and ATF4 inhibition. Users on TRT report no changes to E2, hematocrit, or other markers. That said, we're not doctors — if you're on TRT, discuss any supplement additions with your prescribing physician.
"Is the animal data even relevant to humans?"
The honest answer: we don't know yet. Animal models are useful for establishing mechanism and proof-of-concept, but translation to humans is never guaranteed. The Kunkel, Bongers, and Ogasawara studies provide strong mechanistic evidence. The human data is mixed — one pilot showing recovery benefits, one RCT showing no hypertrophy advantage. More human trials are needed, including in older populations and clinical contexts (there's an ongoing trial in spinal cord injury patients). We're transparent about this because you'd find it out anyway.
"What about the 'gains stay when you stop' claim?"
This is based on the mechanism, not human data. Unlike hormonal compounds that give you temporary water/glycogen fullness (which deflates post-cycle), UA theoretically promotes actual muscle protein synthesis via mTOR activation. Any muscle built through genuine hypertrophy would be retained like normal training-induced muscle. The animal models support this — UA-treated mice maintained muscle after treatment. But we don't have human data specifically measuring retention post-supplementation. It's a reasonable hypothesis, not a proven claim.
"Is it legal and safe?"
Legal: Yes, 100% legal in the US. Ursolic acid is a naturally-occurring triterpenoid found in apple peels, rosemary, and other plants. It's not scheduled, not banned, and not a controlled substance. Safe: Human trials reported no adverse effects at 400-450mg/day over 8 weeks. The Figueiredo 2012 in-vitro study noted that very high doses were myotoxic, indicating there's a dose ceiling — but oral supplementation at normal doses appears well-tolerated. As with anything, don't exceed recommended dosing.
What You're Getting
URONABOL
High-Purity Ursolic Acid
- 3β-hydroxyurs-12-en-28-oic acid
- HPLC-verified purity
- 60ml per bottle (30 servings)
- Liquid format for absorption
- Non-suppressive / No PCT
The Research Summary
✓ Strong Animal Data
Multiple mouse/rat studies showing hypertrophy, strength, and endurance benefits (Kunkel 2011, 2012; Bongers 2015)
± Mixed Human Data
Pilot showed reduced muscle damage markers; RCT showed no hypertrophy advantage in young trained men
✓ Clear Mechanism
mTOR/IGF-1 activation, ATF4 inhibition, MuRF1/Atrogin-1 suppression documented in literature
✓ Good Safety Profile
No adverse effects reported in human trials at 400-450mg/day
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60-Day Money-Back Guarantee
We're confident in the product, but we can't promise it will work for everyone — the human data is mixed, and individual responses vary. Run it for a full cycle, assess your own results, and if you're not satisfied for any reason, contact us within 60 days for a full refund. No interrogation. No hassle.
We'd rather give refunds than have skeptical customers. That's how this should work.
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The Bottom Line
Ursolic acid isn't a miracle compound. The human RCT data is mixed. We told you that upfront.
But the animal data is robust. The mechanism is clear. The Bang pilot showed reduced muscle damage markers. It's non-suppressive, legal, well-tolerated, and stacks with anything. For ~$44/month (with the discount), it's low-risk insurance for your training.
If you're already optimized — young, high protein, structured training — maybe it won't move the needle (see Lobo 2021). But if you're 40+, stressed, recovering between cycles, or looking for any legal edge as a natural lifter, the risk/reward makes sense.
That's the honest pitch. Make your own call.
📄 Key Studies Referenced
Kunkel et al., 2011 (Cell Metabolism) — "mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass" — PubMed
Kunkel et al., 2012 (PLoS ONE) — "Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity" — PubMed
Bongers et al., 2015 (J. Biol. Chem.) — "Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness" — PMC
Ogasawara et al., 2013 — "Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle" — PubMed
Bang et al., 2017 (Pilot Study) — "Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training" — Inha University
Lobo et al., 2021 (RCT — Null Result) — "Ursolic acid has no additional effect on muscle strength and mass in active men undergoing a high-protein diet and resistance training" — PubMed
We include the null result because you'd find it anyway. Read the research yourself.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary. The research cited represents a mix of in-vitro, animal, and human studies with varying levels of evidence. The Lobo et al. 2021 RCT found no significant difference between ursolic acid and placebo for muscle hypertrophy or strength in young trained men on a high-protein diet. Individual responses may differ. Consult with a healthcare professional before starting any supplement regimen. Must be 21 years or older to purchase. Vintage Muscle products are manufactured in the USA in a cGMP certified facility.
URONABOL — High-Purity Ursolic Acid
$87.99 $43.99 50% OFF